|
Angelica sinensis ( Tang Kuei ) , has many functions to improve our health, and then we describe its benefits later. I .Decreaseing constipation due to blood deficiency and dryness of intestine Tang Kuei has enough oil and tastes sweet and moist, so it can nourish blood and moisten intestine. It is good for elder people to defecate comfortably (34).
II . Curing large carbuncle and pyocutaneous disease. Tang Kuei can both nourish blood and promote it circulation. It improves syndromes of inflammation and removes fester of tissue (29,34).
III . Using for blood deficiency syndromes. Tang Kuei applies for patience due to sallow complexion, pale lips, palpitation and whitish nails.
IV .Having anti-oxidized ability to protect normal cells and reduces the risk of cardiovascular disease These observations indicate that the extract of Ligusticum chuanxiong and Angelica sinensis (ELCAS) protected human umbilical vein endothelial cells (ECV304) cells against hydrogen peroxide damage by enhancing the antioxidative ability, activating ERK and eNOS signaling pathway. Our data also provide new evidence of Ligusticum chuanxiong and Tang Kuei in preventing both cardiovascular and cerebrovascular diseases (1). The experimental findings suggest that the total polysaccharide of Angelica sinensis possesses anti-tumor effects on experimental tumor models in vivo and inhibitory effects on invasion and metastasis of hepatocellular carcinoma cells in vitro (9). These results indicate that the Bio-based assays for extracts of Angelica sinensis showed that the acetone extract (AE-AS) could induce G1/S arrest and activate the mechanism of apoptosis in human cancer cells. Extracts obtained from different methods of fractionation might possess distinct bioactivity. These results prompted us to further evaluate the in vivo anticancer effects and elucidate the chemical composition profile of AE-AS (3). Application of agents used for diabetic neuropathy suggests that evening primrose oil, alpha-lipoic acid, and capsaicin may all play a role in the empiric options available to patients with chemotherapy-induced neuropathy. Plant-derived preparations including black cohosh (Actaea racemosa), Tang Kuei, evening primrose (Oenothera biennis), and red clover (Trifolium pretense) are used by patients experiencing hot flashes due to premature menopause despite a paucity of clinical trial data demonstrating either safety or efficacy. Calcium and vitamin D are widely accepted as an effective means to retard bone loss leading to osteoporosis. Nutritional approaches to late effects of breast cancer chemotherapy offer the prospect of preventing or ameliorating these sequelae of treatment. However, except for vitamin D and calcium for prevention of bone loss, current clinical evidence supporting use of nutritional agents remains sparse (6). Tang Kuei, ginseng, and milk thistle had nonspecific immunostimulatory effects on lymphocyte proliferation, whereas ginger and green tea had immunosuppressive effects. Tang Kuei and milk thistle increased alloresponsiveness in mixed lymphocyte culture (MLC), whereas ginger and tea decreased these responses. The immunostimulatory effects of Tang Kuei and milk thistle were consistently seen in both cell-mediated immune response and nonspecific lymphoproliferation, whereas that of ginseng was not. The immunosuppressive effect of green tea and ginger were mediated through a decrease in IL-2 production, but the immunostimulatory effects of Tang Kuei and milk thistle were not (18). Tang Kuei shows strong anti-tumor activity on Ehrlich Ascites tumor bearing mice. It also exhibits immunostimulating activities, both in vitro and in vivo (28). It was found that Tang Kuei increased and C 21 Ester glucoside (GB) decreased the production of IL-2. In the control experiments for immuno-modulating effect, prostaglandin E2 (PGE2) was found to suppress and indomethacin to increase IL-2 production. The stimulatory effect of Tang Kuei was totally abrogated by PGE2(31).
V .Protecting liver cell Kupffer cells play an important role in the modulation of drug metabolic enzymes. The changes of drug metabolic enzyme activities depend on the time of kupffer cell blockade and on the degree of Kupffer cells activated. A low concentration of Angelica sinensis polysaccharides ASP increases the activities of drug metabolic enzymes, but a high concentration of ASP decreases the activities of drug metabolic enzymes(4). Angelica sinensis polysaccharides-enriched fraction (AP) is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver (20).
VI .Decreasing cancer happening due to estrogen inducing Phytoestrogens may serve as chemopreventive agents while at the same time being capable of promoting growth in estrogen receptor positive cancer cell lines. Furthermore, they may exert their estrogenic influence through receptor-dependent and/or receptor-independent mechanisms. These findings have led to speculation that phytoestrogen intake might be ill advised for patients at an increased risk for hormone-dependent cancers, cancer patients, or cancer survivors. This article will attempt to sort out discrepancies between various experimental models and establish whether certain herbs possess estrogenic activity. The review will focus on 5 popular botanical dietary supplements: Trifolium pratense (red clover), Cimicifuga racemosa (black cohosh), Humulus lupulus (hops), Angelica sinensis (Tang Kuei), and Glycyrrhiza glabra (licorice)(10).
VII . Reducing melanin synthesis and tyrosinase activity in vitro Angelica sinensis (Oliv.) promotes melanocytic proliferation, melanin synthesis and tyrosinase activity, which may be the mechanism for validating its clinical use in the treatment of skin pigmentation (12). Aqueous extracts of Angelica sinensis root, a herb commonly used in the treatment of vitiligo in Traditional Chinese Medicine, were tested for their activity on mouse melanocyte proliferation in culture. At concentrations of 0.5-2500 micrograms/ml, these extracts were not able to stimulate melanocyte cell division. On the contrary, they exerted a general cytotoxicity to the cells at higher concentrations. Cytotoxicity was reduced by prior treatment of the extract with polyvinylpolypyrrolidone, which was shown by thin layer chromatography to reduce the coumarin content (27).
VIII .Protecting gastric mucosa A crude extract from Angelica sinensis (ASCE) has a direct wound healing effect on gastric mucosa (13). ASCE has a direct mucosal healing effect on gastric epithelial cells, while ornithine decarboxylase (ODC) and c-Myc are closely associated with this effect (21). ASCE has a direct wound healing effect on gastric mucosa, and this is acting partially through an EGF-mediated pathway (23). Polysaccharides from Angelica possess an anti-inflammatory action, perhaps through the inhibitory action on neutrophil infiltration in the gastrointestinal mucosa. An extract from Angelica , which mainly consisted of polysaccharides (95%) (AP) could potentially be useful to prevent any neutrophil-dependent mucosal injury in the gastrointestinal tract (24).
XI . Proliferating of human bone cells The aqueous extract of Angelica sinensis was found to directly stimulate the proliferation, alkaline phosphatase (ALP) activity, protein secretion and particularly type I collagen synthesis of The human osteoprecursor cells (OPC-1) at dose-dependent manner (19).
X .Reducing cholesterol , triglyceride, low-density lipoproteins and very low-density lipoproteins in serum The Astragalus mongholicus and Angelica sinensis compound (A&A) improves disorders of lipid metabolism perhaps through up-regulating the expression of hepatic LDL-R gene and through increasing the activities of serum LPL and LCAT. |
||||||||||||||||
|
Tel:
+886-2-27755679 +886-2-27755686 Fax: +886-2-27755690 |
|||||||||||||||||
|
@2005Optimized For Internet Explore 5.0 in PC or Safari 1.0 in Mac Best resoution 1024 X 768 All rights reserved Venterinternational Co., Ltd |
|||||||||||||||||
Tang
Kuei'Picture
